Assessing the difference in results of aggregate data meta-analysis and individual patient data meta-analysis

Assessing the difference in results of aggregate data meta-analysis and individual patient data meta-analysis

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There are extensive discussions about the relative merits of performing individual-patient level data (IPD) analysis versus meta-analysis (MA) in those cases where IPD are accessible. Some favor IPD and others favor MA. This study envisages to find the difference in outputs when IPD analysis is done in comparison to standard meta-analysisWhen multiple trials are available for intervention against a standard comparator, it is very difficult to arrive at a single point estimate for the efficacy of the intervention. This research will help us to establish IPD meta-analysis as a tool to establish a point estimate for already existing heterogenous data. Although meta-analysis is widely used to pool aggregate data, there are evidences that pooling of individual patient data might be a more robust method. Our research envisages to further explore this finding. The findings from this study can help us to make more informed decisions regarding the efficacy of an intervention and lead to improvement in patient care.The findings from this study will help to establish IPD meta-analysis as a robust tool to pool data from multiple trials for an intervention. The potential of IPD meta-analysis as a tool to arrive at a point estimate for a heterogenous data can be established.

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