Efficacy of Crohn's Disease Treatment Stratified by Disease Phenotype

Efficacy of Crohn's Disease Treatment Stratified by Disease Phenotype

Crohn's Disease is a heterogenous disorder encompassing multiple clinical phenotypes which arise from different biological pathways. Clinical studies and experience suggest that the efficacy of different agents varies by phenotype including anatomical location, disease behavior, and history of prior medication failure. Although this data is commonly collected in clinical trials, it has not been uniformly analyzed or published. As such, clinicians select between treatments based on best guess of efficacy rather than high-quality evidence. Therefore, we propose to re-analyze this existing clinical trial data as an important step towards enabling precision medicine for Crohn's Disease.

[{ "PostingID": 2360, "Title": "UCB-C87031", "Description": "A Study to Test the Effect of CDP870 in the Treatment of Crohn's Disease Over 26 Weeks, Comparing CDP870 to a Dummy Drug (Placebo)" },{ "PostingID": 2361, "Title": "UCB-C87032", "Description": "Study to Test the Effect of CDP870 in the Treatment of Crohn's Disease Over 26 Weeks, Comparing CDP870 to a Dummy Drug (Placebo), Following 3 Doses of Active Drug (CDP870)." },{ "PostingID": 3918, "Title": "UCB-C87085", "Description": "Study to Evaluate Efficacy and Safety of Certolizumab Pegol for Induction of Remission in Patients With Crohn's Disease" },{ "PostingID": 3919, "Title": "UCB-CDP870037", "Description": "Clinical Study of CDP870/Certolizumab Pegol in Patients With Active Crohn's Disease" }]