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Effects of tumor burden change (response) on survival in mesothelioma
Proposal
2110
Title of Proposed Research
Effects of tumor burden change (response) on survival in mesothelioma
Lead Researcher
Aaron Mansfield
Affiliation
Mayo Clinic
Funding Source
I am funded by the NIH and my time would be used to complete this project with that of Prof. Symanowski's.
Potential Conflicts of Interest
ASCO Lung Cancer Education Committee
Data Sharing Agreement Date
20 March 2018
Lay Summary
Overall survival is the gold standard of end-points for clinical trials in oncology; however, this measurement is complicated by competing mortality and cross-over to other therapies. Responses, or reductions in tumor burden, are commonly analyzed in clinical trials, but nobody has demonstrated whether response rates correlate with survival outcomes in mesothelioma. Demonstration of the correlation of responses with survival outcomes would provide validation to using response rates as endpoints in this disease.
Study Data Provided
Statistical Analysis Plan
The statistical analysis plan will be added after the research is published.
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